Standardization of Assays for Human Chorionic Gonadotropin
نویسندگان
چکیده
منابع مشابه
Standardization of assays for human chorionic gonadotropin.
The unsatisfactory standardization of many immunoassays is fairly well recognized, but the problem is hard to tackle (1 ). Recently, studies on the performance of immunoassays for testosterone in female serum (2 ) and for urinary cortisol (1 ) have revealed that the quality of some widely used assays is totally unsatisfactory. The quality of assays for human chorionic gonadotropin (hCG) has als...
متن کاملDiscordant results in human chorionic gonadotropin assays.
Discordance has been reported in human chorionic gonadotropin (hCG) concentrations measured by different immunoassay kits. We examined the results for 40 serum samples assayed with 10 different hCG immunoassay kits. Results varied considerably. Individual sample results varied by as much as 58-fold. Average results for different kits varied by as much as 1.4-fold for pregnancy (20 samples) and ...
متن کاملInappropriate use of commercial human chorionic gonadotropin assays.
I am disappointed that the recent Q&A article in Clinical Chemistry dealing with assays for human chorionic gonadotropin (hCG) did not mention that all commercial hCG assays in the US are FDA cleared only for the early detection of pregnancy (1 ). The current situation is very unsatisfactory, because these assays, with the knowledge of the manufacturers, are in widespread use for oncology. What...
متن کاملHuman Chorionic Gonadotropin
A highly active preparation of human chorionic gonadotropin has been obtained by simple methods of column chromatography on diethylaminoethyl Sephadex and Sephadex G-100. The preparation appeared homogeneous by disc and immunoelectrophoresis, ultracentrifugation, and end group analysis. It assayed at 12,000 i.u. per mg by the rat prostrate gland and accessory sex organ method. The ~20,~ value w...
متن کاملComparison of 2 human chorionic gonadotropin assays as tumor markers assays.
Intact human chorionic gonadotropin (hCG), hyperglycosylated hCG, and the free subunit are the forms of hCG produced by healthy tissues and tumors (1 ). Intact hCG is the predominant form in serum and plasma in pregnancy and trophoblastic disease, hyperglycosylated hCG in choriocarcinoma and testicular cancer, and the free subunit in nongestational malignancy. Proteases present in macrophages a...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Clinical Chemistry
سال: 2004
ISSN: 0009-9147,1530-8561
DOI: 10.1373/clinchem.2003.031013